OR9A4

Protein-coding gene in the species Homo sapiens
OR9A4
Identifiers
AliasesOR9A4, olfactory receptor family 9 subfamily A member 4
External IDsMGI: 3030294; HomoloGene: 64866; GeneCards: OR9A4; OMA:OR9A4 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for OR9A4
Genomic location for OR9A4
Band7q34Start141,916,399 bp[1]
End141,920,625 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for OR9A4
Genomic location for OR9A4
Band6|6 B1Start40,546,421 bp[2]
End40,551,277 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • bone marrow

  • granulocyte

  • monocyte

  • right coronary artery

  • blood

  • C1 segment
Top expressed in
  • embryo

  • secondary oocyte

  • primary oocyte

  • granulocyte

  • zygote
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • olfactory receptor activity
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

130075

258381

Ensembl

ENSG00000258083

ENSMUSG00000045514

UniProt

Q8NGU2

Q8VF31

RefSeq (mRNA)

NM_001001656

NM_146383

RefSeq (protein)

NP_001001656

NP_666495

Location (UCSC)Chr 7: 141.92 – 141.92 MbChr 6: 40.55 – 40.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 9A4 is a protein that in humans is encoded by the OR9A4 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000258083 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045514 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR9A4 olfactory receptor, family 9, subfamily A, member 4".

Further reading

  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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