OR2T11

Protein-coding gene in the species Homo sapiens
OR2T11
Identifiers
AliasesOR2T11, OR2T11Q, olfactory receptor family 2 subfamily T member 11 (gene/pseudogene), olfactory receptor family 2 subfamily T member 11
External IDsHomoloGene: 84585; GeneCards: OR2T11; OMA:OR2T11 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OR2T11
Genomic location for OR2T11
Band1q44Start248,623,557 bp[1]
End248,635,091 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • kidney

  • human kidney
    n/a
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • signal transducer activity
  • olfactory receptor activity
  • G protein-coupled receptor activity
Cellular component
  • plasma membrane
  • membrane
  • integral component of membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

127077

n/a

Ensembl

ENSG00000279301

n/a

UniProt

Q8NH01

n/a

RefSeq (mRNA)

NM_001001964

n/a

RefSeq (protein)

NP_001001964

n/a

Location (UCSC)Chr 1: 248.62 – 248.64 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptor 2T11 is a protein that in humans is encoded by the OR2T11 gene.[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

Ligands

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000279301 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11".
  4. ^ a b c d Li, S.; et al. (2016). "Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols". J. Am. Chem. Soc. 138 (40): 13281–13288. doi:10.1021/jacs.6b06983. PMID 27659093.

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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