OR4K14

Protein-coding gene in the species Homo sapiens
OR4K14
Identifiers
AliasesOR4K14, OR14-18, OR14-22, olfactory receptor family 4 subfamily K member 14
External IDsHomoloGene: 128265; GeneCards: OR4K14; OMA:OR4K14 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for OR4K14
Genomic location for OR4K14
Band14q11.2Start20,014,143 bp[1]
End20,019,307 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • brain

  • cerebral cortex

  • multicellular organism
    n/a
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • transmembrane signaling receptor activity
  • signal transducer activity
Cellular component
  • membrane
  • plasma membrane
  • integral component of membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • detection of chemical stimulus involved in sensory perception
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

122740

n/a

Ensembl

ENSG00000169484

n/a

UniProt

Q8NGD5

n/a

RefSeq (mRNA)

NM_001004712

n/a

RefSeq (protein)

NP_001004712

n/a

Location (UCSC)Chr 14: 20.01 – 20.02 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptor 4K14 is a protein that in humans is encoded by the OR4K14 gene.[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169484 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: OR4K14 olfactory receptor, family 4, subfamily K, member 14".

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.145.6233. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
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Class II
(tetrapod specific receptors)
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