OR51A7

Protein-coding gene in the species Homo sapiens
OR51A7
Identifiers
AliasesOR51A7, OR11-27, olfactory receptor family 51 subfamily A member 7
External IDsMGI: 3030410; HomoloGene: 45856; GeneCards: OR51A7; OMA:OR51A7 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR51A7
Genomic location for OR51A7
Band11p15.4Start4,903,783 bp[1]
End4,909,462 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR51A7
Genomic location for OR51A7
Band7|7 E3Start102,611,867 bp[2]
End102,624,367 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • fundus

  • prostate
Top expressed in
  • adrenal gland

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

119687

258248

Ensembl

ENSG00000176895

ENSMUSG00000073962

UniProt

Q8NH64

n/a

RefSeq (mRNA)

NM_001004749

NM_001001805

RefSeq (protein)

NP_001004749

n/a

Location (UCSC)Chr 11: 4.9 – 4.91 MbChr 7: 102.61 – 102.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 51A7 is a protein that in humans is encoded by the OR51A7 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

As of 2015, OR51A7 was an orphan receptor, meaning that no odorants have been identified which bind to it.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176895 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073962 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR51A7 olfactory receptor, family 51, subfamily A, member 7".
  6. ^ de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal. 30 (5): 342–361. doi:10.1002/ffj.3249.

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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