Protein-coding gene in the species Homo sapiens
OR7D2 |
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Identifiers |
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Aliases | OR7D2, HTPCRH03, OR19-10, OR19-4, olfactory receptor family 7 subfamily D member 2 |
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External IDs | HomoloGene: 81590; GeneCards: OR7D2; OMA:OR7D2 - orthologs |
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Gene location (Human) |
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![Chromosome 19 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/300px-Ideogram_human_chromosome_19.svg.png) | Chr. | Chromosome 19 (human)[1] |
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| Band | 19p13.2 | Start | 9,178,979 bp[1] |
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End | 9,188,818 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - testicle
- skin of hip
- gonad
- mucosa of transverse colon
- ganglionic eminence
- lower lobe of lung
- ventricular zone
- right testis
- gastrocnemius muscle
- left testis
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| | More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/0/0c/PBB_GE_OR7D2_gnf1h09473_at_fs.png/250px-PBB_GE_OR7D2_gnf1h09473_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - G protein-coupled receptor activity
- olfactory receptor activity
- signal transducer activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
| Biological process | - sensory perception of smell
- detection of chemical stimulus involved in sensory perception of smell
- regulation of transcription, DNA-templated
- signal transduction
- response to stimulus
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 19: 9.18 – 9.19 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Olfactory receptor 7D2 is a protein that in humans is encoded by the OR7D2 gene.[3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000188000 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR7D2 olfactory receptor, family 7, subfamily D, member 2".
Further reading
- Parmentier M, Libert F, Schurmans S, et al. (1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID 1370859. S2CID 43926.
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I (fish-like receptors) | Family 51 | |
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Family 52 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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