OR56A4

Protein-coding gene in humans

OR56A4

Identifiers

Aliases

OR56A4, OR11-49, olfactory receptor family 56 subfamily A member 4

External IDs

MGI: 3030518; HomoloGene: 133596; GeneCards: OR56A4; OMA:OR56A4 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11p15.4	Start	5,999,445 bp^[1]
Band	11p15.4	End	6,006,946 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 E3	Start	104,803,899 bp^[2]
Band	7\|7 E3	End	104,812,860 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	G protein-coupled receptor activity olfactory receptor activity signal transducer activity adrenergic receptor activity dopamine neurotransmitter receptor activity, coupled via Gi/Go dopamine binding
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane synaptic vesicle membrane
Biological process	adenylate cyclase-activating adrenergic receptor signaling pathway sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus synaptic transmission, dopaminergic negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway response to toxic substance regulation of dopamine secretion regulation of potassium ion transport behavioral response to cocaine behavioral response to ethanol negative regulation of cytosolic calcium ion concentration negative regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway negative regulation of voltage-gated calcium channel activity G protein-coupled receptor signaling pathway adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


120793


244187

Ensembl


ENSG00000183389


ENSMUSG00000047225

UniProt


Q8NGH8


Q7TRN8

RefSeq (mRNA)


NM_001005179


NM_207249

RefSeq (protein)


NP_001005179


NP_997132

Location (UCSC)

Chr 11: 6 – 6.01 Mb

Chr 7: 104.8 – 104.81 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Olfactory receptor 56A4 is a protein that in humans is encoded by the OR56A4 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands

Decanal^[6]
Undecanal^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183389 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047225 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR56A4 olfactory receptor, family 56, subfamily A, member 4".
^ Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi:10.1371/journal.pgen.1002821. PMC 3395614. PMID 22807691.
^ Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

External links

OR56A4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

G protein-coupled receptors: olfactory receptors

Class I
(fish-like receptors)

Family 51	A2 A4 A7 B2 B4 B5 B6 D1 E1 E2 F1 F2 G1 G2 H1 I1 I2 L1 M1 Q1 S1 T1 V1
Family 52	A1 A4 A5 B2 B4 B6 D1 E1 E2 E4 E5 E6 E8 H1 I1 I2 J3 K1 K2 L1 L2 M1 N1 N2 N4 N5 P1 R1 W1
Family 56	A1 A3 A4 B1 B4

Class II
(tetrapod specific receptors)

Family 1	A1 A2 B1 C1 D2 D4 D5 E1 E2 E3 F1 F2 G1 I1 J1 J2 J4 K1 L1 L3 L4 L6 L8 M1 N1 N2 Q1 S1 S2
Family 2	A1 A2 A4 A5 A7 A12 A14 A25 A42 AE1 AG1 AG2 AJ1 AK2 AP1 AT4 B2 B3 B6 B8 B11 C1 C3 D2 D3 F1 F2 G2 G3 G6 H1 H2 J1 J2 J3 K2 L2 L3 L5 L8 L13 M2 M3 M4 M5 M7 S2 T1 T2 T3 T4 T5 T6 T8 T10 T11 T12 T27 T29 T33 T34 T35 V1 V2 W1 W3 W5 Y1 Z1
Family 3	A1 A2 A3 A4
Family 4	A5 A15 A16 A47 B1 C3 C5 C6 C11 C12 C13 C15 C16 C45 C46 D1 D2 D5 D6 D9 D10 D11 E2 F3 F4 F5 F6 F15 F16 F17 F21 F29 K1 K2 K3 K5 K13 K14 K15 K17 L1 M1 M2 N2 N4 N5 P4 Q3 S1 S2 X1 X2
Family 5	A1 A2 AC2 AK2 AK3 AN1 AP2 AR1 AS1 AT1 AU1 AY1 B2 B3 B12 B17 B21 BF1 BU1 C1 D13 D14 D16 D18 F1 H1 H2 H6 H14 H15 I1 J2 K1 K2 K3 K4 L1 L2 M1 M3 M8 M9 M10 M11 P2 P3 R1 T1 T2 T3 U1 V1 W2
Family 6	A2 B1 B2 B3 C1 C2 C3 C4 C6 C65 C68 C70 C74 C75 C76 F1 J1 K2 K3 K6 M1 N1 N2 P1 Q1 S1 T1 V1 X1 Y1
Family 7	A2 A5 A10 A17 C1 C2 D2 D4 E24 G1 G2 G3
Family 8	A1 B2 B3 B4 B8 B12 D1 D2 D4 G1 G2 G5 H1 H2 H3 I2 J1 J3 K1 K3 K5 S1 U1
Family 9	A2 A4 G1 G4 I1 K2 Q1 Q2
Family 10	A2 A3 A4 A5 A6 A7 AD1 AG1 C1 D4 G2 G3 G4 G6 G7 G8 G9 H1 H2 H3 H4 H5 J1 J3 J5 J6 K1 K2 P1 Q1 R2 S1 T2 V1 W1 X1 Z1
Family 11	A1 G2 H1 H4 H6 L1
Family 12	D2 D3
Family 13	A1 C2 C3 C4 C5 C8 C9 D1 F1 G1 H1 J1