OR5B12

Protein-coding gene in the species Homo sapiens
OR5B12
Identifiers
AliasesOR5B12, OR11-241, OR5B12P, OR5B16, OST743, olfactory receptor family 5 subfamily B member 12
External IDsMGI: 3031279; HomoloGene: 133606; GeneCards: OR5B12; OMA:OR5B12 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR5B12
Genomic location for OR5B12
Band11q12.1Start58,438,994 bp[1]
End58,442,236 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for OR5B12
Genomic location for OR5B12
Band19|19 AStart12,861,219 bp[2]
End12,862,219 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • lymph node

  • gallbladder

  • human musculoskeletal system

  • skeletal striated muscle

  • muscle of leg

  • gastrocnemius muscle
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • odorant binding
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

390191

258694

Ensembl

ENSG00000172362

ENSMUSG00000045126

UniProt

Q96R08

Q8VFW9

RefSeq (mRNA)

NM_001004733

NM_146699

RefSeq (protein)

NP_001004733

NP_666910

Location (UCSC)Chr 11: 58.44 – 58.44 MbChr 19: 12.86 – 12.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 5B12 is a protein that in humans is encoded by the OR5B12 gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172362 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045126 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (Sep 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.145.6233. doi:10.1006/geno.2002.6830. PMID 12213199.
  6. ^ a b "Entrez Gene: OR5B12 olfactory receptor, family 5, subfamily B, member 12".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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