OR6C4

Protein-coding gene in the species Homo sapiens
OR6C4
Identifiers
AliasesOR6C4, OR12-10, olfactory receptor family 6 subfamily C member 4
External IDsHomoloGene: 79371; GeneCards: OR6C4; OMA:OR6C4 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for OR6C4
Genomic location for OR6C4
Band12q13.2Start55,549,602 bp[1]
End55,555,832 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gallbladder

  • lobe of thyroid gland

  • left lobe of thyroid gland

  • respiratory system

  • intestine

  • circulatory system

  • colon

  • thoracic segment of trunk

  • leg

  • subdivision of respiratory system
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

341418

n/a

Ensembl

ENSG00000179626

n/a

UniProt

Q8NGE1

n/a

RefSeq (mRNA)

NM_001005494
NM_001385975

n/a

RefSeq (protein)

NP_001005494

n/a

Location (UCSC)Chr 12: 55.55 – 55.56 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptor 6C4 is a protein that in humans is encoded by the OR6C4 gene.[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179626 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: OR6C4 olfactory receptor, family 6, subfamily C, member 4".

Further reading

  • Lauzurica P, Bragado R, López D, Galocha B, López De Castro JA (1992). "Asymmetric selection of T cell antigen receptor alpha- and beta-chains in HLA-B27 alloreactivity". J. Immunol. 148 (11): 3624–30. doi:10.4049/jimmunol.148.11.3624. PMID 1316921.
  • Youngblood K, Fruchter L, Ding G, Lopez J, Bonagura V, Davidson A (1994). "Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated". J. Clin. Invest. 93 (2): 852–61. doi:10.1172/JCI117040. PMC 293948. PMID 7509350.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e
Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


Stub icon

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e