OR10A7

Protein-coding gene in the species Homo sapiens
OR10A7
Identifiers
AliasesOR10A7, OR12-6, olfactory receptor family 10 subfamily A member 7
External IDsHomoloGene: 78831; GeneCards: OR10A7; OMA:OR10A7 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for OR10A7
Genomic location for OR10A7
Band12q13.2Start55,221,025 bp[1]
End55,221,975 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

121364

n/a

Ensembl

ENSG00000179919

n/a

UniProt

Q8NGE5

n/a

RefSeq (mRNA)

NM_001005280

n/a

RefSeq (protein)

NP_001005280

n/a

Location (UCSC)Chr 12: 55.22 – 55.22 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptor 10A7 is a protein that in humans is encoded by the OR10A7 gene.[3]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179919 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: OR10A7 olfactory receptor, family 10, subfamily A, member 7".

Further reading

  • Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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(fish-like receptors)
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(tetrapod specific receptors)
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