OR5H6

Protein-coding gene in the species Homo sapiens
OR5H6
Identifiers
AliasesOR5H6, OR3-11, olfactory receptor family 5 subfamily H member 6 (gene/pseudogene), olfactory receptor family 5 subfamily H member 6
External IDsMGI: 3030021; HomoloGene: 133069; GeneCards: OR5H6; OMA:OR5H6 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for OR5H6
Genomic location for OR5H6
Band3q11.2Start98,263,252 bp[1]
End98,265,356 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for OR5H6
Genomic location for OR5H6
Band16|16 C1.3Start58,855,926 bp[2]
End58,860,130 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • odorant binding
  • signal transducer activity
  • olfactory receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79295

258319

Ensembl

ENSG00000230301

ENSMUSG00000043357

UniProt

Q8NGV6

Q8VEX6

RefSeq (mRNA)

NM_001005479

NM_146322

RefSeq (protein)

NP_001005479

NP_666434

Location (UCSC)Chr 3: 98.26 – 98.27 MbChr 16: 58.86 – 58.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 5H6 is a protein that in humans is encoded by the OR5H6 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000230301 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043357 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR5H6 olfactory receptor, family 5, subfamily H, member 6".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
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Class II
(tetrapod specific receptors)
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