ZAK

MAP3K20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5HES
Identifiers
Aliases	MAP3K20, AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, ZAK, SFMMP, sterile alpha motif and leucine zipper containing kinase AZK, mitogen-activated protein kinase kinase kinase 20, MLTKalpha, MLTKbeta, CNM6
External IDs	OMIM: 609479; MGI: 2443258; HomoloGene: 32331; GeneCards: MAP3K20; OMA:MAP3K20 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 173,075,435 bp[1] End 173,268,015 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 72,115,981 bp[2] End 72,272,954 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii body of tongue saphenous vein tail of epididymis vena cava urethra seminal vesicula Top expressed in interventricular septum temporal muscle ankle triceps brachii muscle digastric muscle extraocular muscle sternocleidomastoid muscle soleus muscle atrioventricular valve intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity metal ion binding kinase activity protein serine/threonine kinase activity protein binding MAP kinase kinase kinase activity ATP binding magnesium ion binding RNA binding Cellular component nucleus cytoplasm cytosol Biological process cell differentiation intracellular signal transduction cell cycle checkpoint signaling phosphorylation DNA damage checkpoint signaling response to stress cell death protein phosphorylation cytoskeleton organization positive regulation of apoptotic process cell cycle response to radiation cell population proliferation embryonic digit morphogenesis limb development mitotic cell cycle checkpoint signaling stress-activated MAPK cascade cellular response to gamma radiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51776 65964 Ensembl ENSG00000091436 ENSMUSG00000004085 UniProt Q9NYL2 Q9ESL4 RefSeq (mRNA) NM_016653 NM_133646 NM_001164791 NM_023057 NM_178084 RefSeq (protein) NP_057737 NP_598407 NP_001158263 NP_075544 NP_835185 Location (UCSC) Chr 2: 173.08 – 173.27 Mb Chr 2: 72.12 – 72.27 Mb PubMed search [3] [4]
Wikidata
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Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.^[5]

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^{[5] [6]}

Interactions

ZAK has been shown to interact with ZNF33A.^[7]

References

• Lee, Jin-Sun (28 February 2018). "Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK". The Chinese Journal of Physiology. 61 (1): 25–34. doi:10.4077/CJP.2018.BAG528. PMID 29374956.

Further reading

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