Cisteinil leukotrienski receptor 1

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Cisteinil leukotrienski receptor 1
Identifikatori
SimboliCYSLTR1; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81
Vanjski IDOMIM: 300201 MGI: 1926218 HomoloGene: 4837 IUPHAR: CysLT1 GeneCards: CYSLTR1 Gene
Ontologija gena
Molekularna funkcija • aktivnost prenosa signala
• receptorska aktivnost
• aktivnost leukotrienskog receptora
Celularna komponenta • membranska frakcija
• ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • transport kalcijumskih jona
• hemotaksa
• odbrambeni respons
• inflamatorni respons
• povišenje koncentracije citozolinih kalcijumovih jona
• razmena respiratornih gasova
• pozitivna regulacija vazokonstrikcije
Ortolozi
VrstaČovekMiš
Entrez1080058861
EnsemblENSG00000173198ENSMUSG00000052821
UniProtQ9Y271Q99JA4
RefSeq (mRNA)NM_006639.2NM_021476.4
RefSeq (protein)NP_006630.1NP_067451.2
Lokacija (UCSC)Chr X:
77.53 - 77.58 Mb		Chr X:
103.77 - 103.8 Mb
PubMed pretraga[1][2]

Cisteinil leukotrienski receptor 1 je protein koji je kod ljudi kodiran CYSLTR1 genom.[1][2][3]

Cisteinil leukotrieni LTC4, LTD4 i LTE4 su posrednici ljudske bronhijalne astme. Farmakološke studije su utvrdile da cisteinil leukotrieni aktiviraju najmanje 2 receptora, protein kodiran ovim genom i CYSLTR2. Ovaj receptor je član superfamilije G protein spregnutih receptora. Aktivacija ovog receptora LTD4 ligandom dovodi kontrakcija i proliferacije glatkih mišića, eozinofilne migracije i oštećenja sluznog sloja pluća.[3]

Reference

  1. ↑ Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF (Jul 1999). „Characterization of the human cysteinyl leukotriene CysLT1 receptor”. Nature 399 (6738): 789–93. DOI:10.1038/21658. PMID 10391245. 
  2. ↑ Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW (Sep 1999). „Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor”. Mol Pharmacol 56 (3): 657–63. PMID 10462554. 
  3. ↑ 3,0 3,1 „Entrez Gene: CYSLTR1 cysteinyl leukotriene receptor 1”. 

Literatura

  • Gronert K, Martinsson-Niskanen T, Ravasi S, et al. (2001). „Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses.”. Am. J. Pathol. 158 (1): 3–9. DOI:10.1016/S0002-9440(10)63937-5. PMC 1850279. PMID 11141472. 
  • Sjöström M, Jakobsson PJ, Heimburger M, et al. (2001). „Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.”. Eur. J. Biochem. 268 (9): 2578–86. DOI:10.1046/j.1432-1327.2001.02142.x. PMID 11322876. 
  • Mellor EA, Maekawa A, Austen KF, Boyce JA (2001). „Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells.”. Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7964–9. DOI:10.1073/pnas.141221498. PMC 35451. PMID 11438743. 
  • Mita H, Hasegawa M, Saito H, Akiyama K (2002). „Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils.”. Clin. Exp. Allergy 31 (11): 1714–23. DOI:10.1046/j.1365-2222.2001.01184.x. PMID 11696047. 
  • Shirasaki H, Kanaizumi E, Watanabe K, et al. (2003). „Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa.”. Clin. Exp. Allergy 32 (7): 1007–12. DOI:10.1046/j.1365-2222.2002.01425.x. PMID 12100046. 
  • Ohshima N, Nagase H, Koshino T, et al. (2002). „A functional study on CysLT(1) receptors in human eosinophils.”. Int. Arch. Allergy Immunol. 129 (1): 67–75. DOI:10.1159/000065175. PMID 12373000. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ohd JF, Nielsen CK, Campbell J, et al. (2003). „Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas.”. Gastroenterology 124 (1): 57–70. DOI:10.1053/gast.2003.50011. PMID 12512030. 
  • Chibana K, Ishii Y, Asakura T, Fukuda T (2003). „Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin.”. J. Immunol. 170 (8): 4290–5. PMID 12682264. 
  • Espinosa K, Bossé Y, Stankova J, Rola-Pleszczynski M (2003). „CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4.”. J. Allergy Clin. Immunol. 111 (5): 1032–40. DOI:10.1067/mai.2003.1451. PMID 12743568. 
  • Walch L, Norel X, Gascard JP, Brink C (2003). „Arachidonic acid inhibits cysteinyl-leukotriene receptor activation in human pulmonary vessels.”. Adv. Exp. Med. Biol. 525: 75–9. PMID 12751740. 
  • Nielsen CK, Ohd JF, Wikström K, et al. (2003). „The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.”. Adv. Exp. Med. Biol. 525: 201–4. PMID 12751768. 
  • Mechiche H, Naline E, Candenas L, et al. (2003). „Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites.”. Clin. Exp. Allergy 33 (7): 887–94. DOI:10.1046/j.1365-2222.2003.01696.x. PMID 12859443. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Yang G, Haczku A, Chen H, et al. (2004). „Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4.”. Am. J. Physiol. Lung Cell Mol. Physiol. 286 (5): L992–1001. DOI:10.1152/ajplung.00367.2003. PMID 15064240. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Naik S, Billington CK, Pascual RM, et al. (2005). „Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling.”. J. Biol. Chem. 280 (10): 8722–32. DOI:10.1074/jbc.M413014200. PMID 15590629. 
  • Corrigan C, Mallett K, Ying S, et al. (2005). „Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis.”. J. Allergy Clin. Immunol. 115 (2): 316–22. DOI:10.1016/j.jaci.2004.10.051. PMID 15696087. 

Spoljašnje veze

  • „Leukotriene Receptors: CysLT1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 

Vidi još

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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)