Spo11

識別號

SPO11；, CT35, SPATA43, TOPVIA, initiator of meiotic double stranded breaks, SPO11 initiator of meiotic double stranded breaks, Meiotic recombination, Spo11, Meiotic_Spo11, IPR013048, Spo11, TOPOVIA

外部ID

OMIM：605114 MGI：1349669 HomoloGene：6059 GeneCards：SPO11

基因位置（人类）

染色体	20號染色體^[1]

基因座	20q13.31	起始	57,329,803 bp^[1]
基因座	20q13.31	终止	57,343,994 bp^[1]

基因位置（小鼠）

染色体	小鼠2号染色体^[2]

基因座	2 H3\|2 95.64 cM	起始	172,819,493 bp^[2]
基因座	2 H3\|2 95.64 cM	终止	172,835,369 bp^[2]

基因本體
分子功能	• 金屬離子結合 • 催化活性 • 水解酶活性 • ATP結合 • 血浆蛋白结合 • isomerase activity • DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity • endodeoxyribonuclease activity, producing 3'-phosphomonoesters • DNA结合
細胞組分	• 染色体 • 端粒 • 细胞核 • nuclear chromosome
生物學過程	• protein localization to chromosome • 雌配子发生 • meiotic telomere clustering • male meiosis I • DNA代谢过程 • DNA catabolic process, endonucleolytic • 卵子发生 • homologous chromosome pairing at meiosis • 減數分裂 • synaptonemal complex assembly • 精子发生 • spermatid development • ovarian follicle development • meiotic DNA double-strand break processing • meiotic DNA double-strand break formation • reciprocal meiotic recombination • double-strand break repair involved in meiotic recombination
Sources:Amigo / QuickGO

直系同源

物種

人類

小鼠

Entrez


23626


26972

Ensembl


ENSG00000054796


ENSMUSG00000005883

UniProt


Q9Y5K1 Q5TCH6


Q9WTK8

mRNA序列


NM_012444 NM_198265


NM_001083959 NM_001083960 NM_012046 NM_001305434

蛋白序列


NP_036576 NP_937998


NP_001077428 NP_001077429 NP_001292363 NP_036176

基因位置（UCSC）

Chr 20: 57.33 – 57.34 Mb

Chr 2: 172.82 – 172.84 Mb

PubMed查找

^[3]

^[4]

維基數據

檢視/編輯人類

檢視/編輯小鼠

Spo11是人类基因spo11 编码的蛋白质，在真核生物中广泛存在，与古菌基因TopVIA为直系同源体，负责减数第一次分裂前期遺傳重組中DNA的双链断裂的形成^[5]^[6]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000054796 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000005883 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A, et al. A DNA topoisomerase VI-like complex initiates meiotic recombination. Science. February 2016, 351 (6276): 939–43 [2020-08-29]. Bibcode:2016Sci...351..939V. PMID 26917763. S2CID 206643600. doi:10.1126/science.aad5196. （原始内容存档于2020-07-11）.
^ Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. February 2016, 351 (6276): 943–9 [2020-08-29]. Bibcode:2016Sci...351..943R. PMID 26917764. S2CID 9445593. doi:10.1126/science.aad5309. （原始内容存档于2020-07-11）.