ARD1A

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N-(alfa)-acetiltransferaza 10, NatA katalitička podjedinica
Identifikatori
SimboliNAA10; ARD1; ARD1A; DXS707; NATD; TE2
Vanjski IDOMIM: 300013 MGI: 1915255 HomoloGene: 2608 GeneCards: NAA10 Gene
EC broj2.3.1.88
Ontologija gena
Molekularna funkcija • aktivnost peptidne alfa-N-acetiltransferaze
• proteinsko vezivanje
• N-acetiltransferazna aktivnost
Celularna komponenta • intracelularni
• nukleus
• citoplazma
Biološki proces • DNK pakiranje
• N-terminalna proteinska aminokiselinska acetilacija
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez826056292
EnsemblENSG00000102030ENSMUSG00000031388
UniProtP41227Q9QY36
RefSeq (mRNA)NM_001256119NM_001177965
RefSeq (protein)NP_001243048NP_001171436
Lokacija (UCSC)Chr HG1497_PATCH:
153.14 - 153.14 Mb		Chr X:
73.92 - 73.92 Mb
PubMed pretraga[1][2]

N-terminalni acetiltransferazni kompleks ARD1, homolog A je enzim koji je kod čoveka kodiran ARD1A genom.[1][2]

Reference

  1. ↑ Tribioli C, Mancini M, Plassart E, Bione S, Rivella S, Sala C, Torri G, Toniolo D (Jan 1995). „Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae”. Hum Mol Genet 3 (7): 1061–7. DOI:10.1093/hmg/3.7.1061. PMID 7981673. 
  2. ↑ „Entrez Gene: ARD1A ARD1 homolog A, N-acetyltransferase (S. cerevisiae)”. 

Literatura

  • Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). „Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.”. Genomics 44 (1): 8–14. DOI:10.1006/geno.1997.4822. PMID 9286695. 
  • Hartley JL, Temple GF, Brasch MA (2001). „DNA cloning using in vitro site-specific recombination.”. Genome Res. 10 (11): 1788–95. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). „Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.”. EMBO Rep. 1 (3): 287–92. DOI:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. 
  • Jeong JW, Bae MK, Ahn MY, et al. (2003). „Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.”. Cell 111 (5): 709–20. DOI:10.1016/S0092-8674(02)01085-1. PMID 12464182. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Sugiura N, Adams SM, Corriveau RA (2003). „An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development.”. J. Biol. Chem. 278 (41): 40113–20. DOI:10.1074/jbc.M301218200. PMID 12888564. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). „From ORFeome to biology: a functional genomics pipeline.”. Genome Res. 14 (10B): 2136–44. DOI:10.1101/gr.2576704. PMC 528930. PMID 15489336. 
  • Arnesen T, Anderson D, Baldersheim C, et al. (2005). „Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.”. Biochem. J. 386 (Pt 3): 433–43. DOI:10.1042/BJ20041071. PMC 1134861. PMID 15496142. 
  • Asaumi M, Iijima K, Sumioka A, et al. (2005). „Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion.”. J. Biochem. 137 (2): 147–55. DOI:10.1093/jb/mvi014. PMID 15749829. 
  • Fisher TS, Etages SD, Hayes L, et al. (2005). „Analysis of ARD1 function in hypoxia response using retroviral RNA interference.”. J. Biol. Chem. 280 (18): 17749–57. DOI:10.1074/jbc.M412055200. PMID 15755738. 
  • Bilton R, Mazure N, Trottier E, et al. (2005). „Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF.”. J. Biol. Chem. 280 (35): 31132–40. DOI:10.1074/jbc.M504482200. PMID 15994306. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 
  • Arnesen T, Gromyko D, Horvli O, et al. (2006). „Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms.”. Thyroid 15 (10): 1131–6. DOI:10.1089/thy.2005.15.1131. PMID 16279846. 
  • Arnesen T, Kong X, Evjenth R, et al. (2006). „Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha.”. FEBS Lett. 579 (28): 6428–32. DOI:10.1016/j.febslet.2005.10.036. PMID 16288748. 
  • Kim SH, Park JA, Kim JH, et al. (2006). „Characterization of ARD1 variants in mammalian cells.”. Biochem. Biophys. Res. Commun. 340 (2): 422–7. DOI:10.1016/j.bbrc.2005.12.018. PMID 16376303. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). „The LIFEdb database in 2006.”. Nucleic Acids Res. 34 (Database issue): D415–8. DOI:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. 
  • Arnesen T, Gromyko D, Pendino F, et al. (2006). „Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex.”. Oncogene 25 (31): 4350–60. DOI:10.1038/sj.onc.1209469. PMID 16518407. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). „A probability-based approach for high-throughput protein phosphorylation analysis and site localization.”. Nat. Biotechnol. 24 (10): 1285–92. DOI:10.1038/nbt1240. PMID 16964243. 
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2.3.1: osim amino-acilne grupe2.3.2: Aminoaciltransferaze2.3.3: konverzija u alkil pri transferu
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6