| TLR4 |
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| 사용 가능한 구조 |
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| PDB | 동원체 검색: PDBe RCSB |
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| PDB ID 코드 목록 |
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4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA |
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| 식별자 |
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| 다른 이름 | TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4 |
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| 외부 ID | OMIM: 603030 MGI: 96824 HomoloGene: 41317 GeneCards: TLR4 |
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| RNA 발현 패턴 |
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| Bgee | | 인간 | 쥐(동원체) |
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| 최상위 발현 | - 단핵구
- 아킬레스건
- 혈액
- 골수
- 해면뼈
- 비장
- 과립구
- 오른허파
- 쓸개
- 골수세포
|
| | 최상위 발현 | - lumbar spinal ganglion
- 대동맥 판막
- 상행대동맥
- 과립구
- decidua
- epithelium of stomach
- stroma of bone marrow
- endothelial cell of lymphatic vessel
- 자궁경부
- mucous cell of stomach
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| | 추가 참조 발현 데이터 |
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| BioGPS |  | | 추가 참조 발현 데이터 |
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| 유전자 온톨로지 |
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| 분자 함수 | - lipopolysaccharide immune receptor activity
- 지질다당류 결합
- 단백질 결합
- transmembrane signaling receptor activity
| | 세포 성분 | - 세포질
- 세포막
- perinuclear region of cytoplasm
- 세포 표면
- integral component of membrane
- 세포막
- endosome membrane
- intrinsic component of plasma membrane
- integral component of plasma membrane
- lipopolysaccharide receptor complex
- external side of plasma membrane
| | 생물학적 과정 | - positive regulation of MHC class II biosynthetic process
- positive regulation of JNK cascade
- TRIF-dependent toll-like receptor signaling pathway
- cellular response to mechanical stimulus
- positive regulation of interleukin-8 production
- positive regulation of ERK1 and ERK2 cascade
- T-helper 1 type immune response
- positive regulation of platelet activation
- positive regulation of interleukin-1 production
- positive regulation of stress-activated MAPK cascade
- positive regulation of NLRP3 inflammasome complex assembly
- positive regulation of interleukin-12 production
- positive regulation of interferon-alpha production
- I-kappaB phosphorylation
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of B cell proliferation
- 세균에 대한 방어 반응
- positive regulation of interleukin-6 production
- activation of innate immune response
- positive regulation of tumor necrosis factor production
- negative regulation of tumor necrosis factor production
- 선천면역
- negative regulation of interleukin-17 production
- I-kappaB kinase/NF-kappaB signaling
- positive regulation of interferon-beta production
- positive regulation of inflammatory response
- toll-like receptor 4 signaling pathway
- positive regulation of macrophage cytokine production
- positive regulation of interleukin-10 production
- 면역 과정
- astrocyte development
- intestinal epithelial structure maintenance
- positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
- response to lipopolysaccharide
- cellular response to lipoteichoic acid
- 전사인자 NF-kB 활성의 상향조절
- 면역반응
- negative regulation of interleukin-23 production
- regulation of inflammatory response
- positive regulation of chemokine production
- lipopolysaccharide-mediated signaling pathway
- detection of fungus
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- negative regulation of interferon-gamma production
- response to bacterium
- negative regulation of osteoclast differentiation
- B cell proliferation involved in immune response
- positive regulation of nitric oxide biosynthetic process
- negative regulation of interleukin-6 production
- positive regulation of interferon-gamma production
- nitric oxide production involved in inflammatory response
- MyD88-dependent toll-like receptor signaling pathway
- regulation of dendritic cell cytokine production
- positive regulation of gene expression
- negative regulation of ERK1 and ERK2 cascade
- I-kB/NF-kB 신호전달의 상향조절
- macrophage activation
- detection of lipopolysaccharide
- cellular response to lipopolysaccharide
- positive regulation of lymphocyte proliferation
- positive regulation of transcription by RNA polymerase II
- MyD88-independent toll-like receptor signaling pathway
- 신호전달
- inflammatory response
- defense response to Gram-negative bacterium
- toll-like receptor signaling pathway
- necroptosis
- apoptotic signaling pathway
- negative regulation of MyD88-independent toll-like receptor signaling pathway
| | 출처: Amigo / QuickGO |
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| 동원체 |
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| 종 | 인간 | 쥐 |
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| 앙트레 | | |
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| 앙상블 | | |
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| 유니프롯 | | |
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| RefSeq (mRNA) | |
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NM_138557
NM_003266
NM_138554
NM_138556 |
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| RefSeq(단백질) | |
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NP_003257
NP_612564
NP_612567 |
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| 위치(UCSC) | Chr 9: 117.7 – 117.72 Mb | Chr 4: 66.75 – 66.85 Mb |
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| PubMed 검색 | [3] | [4] |
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| 위키데이터 |
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