PPARGC1B

El coactivador del receptor gamma 1-beta activado por el proliferador de peroxisomas es una proteína que en humanos está codificada por el gen PPARGC1B.[1]​[2]​[3]​

Véase también

Referencias

  1. ↑ «Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus». Diabetologia 44 (12): 2220-6. Jan 2002. PMID 11793024. doi:10.1007/s001250100032. 
  2. ↑ «The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha». J Biol Chem 277 (16): 13918-25. Apr 2002. PMID 11854298. doi:10.1074/jbc.M201134200. 
  3. ↑ «Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta». 

Bibliografía

  • Handschin C, Spiegelman BM (2007). «Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.». Endocr. Rev. 27 (7): 728-35. PMID 17018837. doi:10.1210/er.2006-0037. 
  • Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). «Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression.». Genomics 62 (1): 98-102. PMID 10585775. doi:10.1006/geno.1999.5977. 
  • Knutti D, Kaul A, Kralli A (2000). «A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.». Mol. Cell. Biol. 20 (7): 2411-22. PMC 85422. PMID 10713165. doi:10.1128/MCB.20.7.2411-2422.2000. 
  • Lin J, Puigserver P, Donovan J, etal (2002). «Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.». J. Biol. Chem. 277 (3): 1645-8. PMID 11733490. doi:10.1074/jbc.C100631200. 
  • Lacquemant C, Chikri M, Boutin P, etal (2002). «No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians.». Diabetologia 45 (4): 602-3; author reply 604. PMID 12032643. doi:10.1007/s00125-002-0783-z. 
  • Hara K, Tobe K, Okada T, etal (2003). «A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.». Diabetologia 45 (5): 740-3. PMID 12107756. doi:10.1007/s00125-002-0803-z. 
  • Huss JM, Kopp RP, Kelly DP (2002). «Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha.». J. Biol. Chem. 277 (43): 40265-74. PMID 12181319. doi:10.1074/jbc.M206324200. 
  • Hentschke M, Süsens U, Borgmeyer U (2003). «PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.». Biochem. Biophys. Res. Commun. 299 (5): 872-9. PMID 12470660. doi:10.1016/S0006-291X(02)02753-5. 
  • Strausberg RL, Feingold EA, Grouse LH, etal (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Shiraki T, Sakai N, Kanaya E, Jingami H (2003). «Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state.». J. Biol. Chem. 278 (13): 11344-50. PMID 12551939. doi:10.1074/jbc.M212859200. 
  • Hammarstedt A, Jansson PA, Wesslau C, etal (2003). «Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.». Biochem. Biophys. Res. Commun. 301 (2): 578-82. PMID 12565902. doi:10.1016/S0006-291X(03)00014-7. 
  • Meirhaeghe A, Crowley V, Lenaghan C, etal (2003). «Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo.». Biochem. J. 373 (Pt 1): 155-65. PMC 1223480. PMID 12678921. doi:10.1042/BJ20030200. 
  • Patti ME, Butte AJ, Crunkhorn S, etal (2003). «Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.». Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8466-71. PMC 166252. PMID 12832613. doi:10.1073/pnas.1032913100. 
  • Ota T, Suzuki Y, Nishikawa T, etal (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40-5. PMID 14702039. doi:10.1038/ng1285. 
  • Ling C, Poulsen P, Carlsson E, etal (2004). «Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.». J. Clin. Invest. 114 (10): 1518-26. PMC 525741. PMID 15546003. doi:10.1172/JCI21889. 
  • Andersen G, Wegner L, Yanagisawa K, etal (2006). «Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.». J. Med. Genet. 42 (5): 402-7. PMC 1736055. PMID 15863669. doi:10.1136/jmg.2004.026278. 
  • Staiger H, Staiger K, Haas C, etal (2005). «Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro.». Diabetologia 48 (10): 2115-8. PMID 16132959. doi:10.1007/s00125-005-1895-z. 
  • Wirtenberger, M., Tchatchou, S., Hemminki, K., et al. (2006). «Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.». Carcinogenesis 27 (11): 2201-8. PMID 16704985. doi:10.1093/carcin/bgl067. 

Enlaces externos

  • MeSH: PPARGC1B protein, human (en inglés)

Este artículo incorpora texto de la Biblioteca Nacional de Medicina de los Estados Unidos, que se encuentra en el dominio público.

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  • Wd Datos: Q18050472
  • Identificadores médicos
  • OMIM: 608886
  • UMLS: C1428918
  • Identificadores biológicos
  • HomoloGene: 15776
  • Wd Datos: Q18050472