UNQ1887

Protein-coding gene in the species Homo sapiens

SPPL3

Identifiers

Aliases

SPPL3, IMP2, MDHV1887, PRO4332, PSH1, PSL4, UNQ1887, signal peptide peptidase like 3

External IDs

OMIM: 608240; MGI: 1891433; HomoloGene: 15563; GeneCards: SPPL3; OMA:SPPL3 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q24.31	Start	120,762,510 bp^[1]
Band	12q24.31	End	120,904,358 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 F	Start	115,149,196 bp^[2]
Band	5\|5 F	End	115,236,849 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of arm

skin of leg

mucosa of ileum

nipple

skin of abdomen

skin of thigh

skin of hip

secondary oocyte

mucosa of esophagus

human penis

Top expressed in

cumulus cell

corneal stroma

Ileal epithelium

hair follicle

CA3 field

conjunctival fornix

perirhinal cortex

entorhinal cortex

ciliary body

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein homodimerization activity aspartic-type endopeptidase activity aspartic endopeptidase activity, intramembrane cleaving peptidase activity protein binding hydrolase activity
Cellular component	integral component of membrane rough endoplasmic reticulum Golgi apparatus endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle integral component of cytoplasmic side of endoplasmic reticulum membrane plasma membrane endoplasmic reticulum Golgi-associated vesicle membrane integral component of lumenal side of endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment membrane lysosomal membrane
Biological process	positive regulation of protein dephosphorylation membrane protein proteolysis positive regulation of cytosolic calcium ion concentration proteolysis membrane protein ectodomain proteolysis positive regulation of protein binding T cell receptor signaling pathway positive regulation of calcineurin-NFAT signaling cascade signal peptide processing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


121665


74585

Ensembl


ENSG00000157837


ENSMUSG00000029550

UniProt


Q8TCT6


Q9CUS9

RefSeq (mRNA)


NM_139015


NM_029012

RefSeq (protein)


NP_620584


NP_083288

Location (UCSC)

Chr 12: 120.76 – 120.9 Mb

Chr 5: 115.15 – 115.24 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Signal peptide peptidase 3, also known as UNQ1887, is a human gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157837 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029550 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: UNQ1887 signal peptide peptidase 3".

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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Weihofen A, Binns K, Lemberg MK, et al. (2002). "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science. 296 (5576): 2215–8. Bibcode:2002Sci...296.2215W. doi:10.1126/science.1070925. PMID 12077416. S2CID 45633906.
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Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Friedmann E, Lemberg MK, Weihofen A, et al. (2005). "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins". J. Biol. Chem. 279 (49): 50790–8. doi:10.1074/jbc.M407898200. hdl:2262/89311. PMID 15385547.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Krawitz P, Haffner C, Fluhrer R, et al. (2006). "Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3". J. Biol. Chem. 280 (47): 39515–23. doi:10.1074/jbc.M501645200. PMID 15998642.
Nyborg AC, Ladd TB, Jansen K, et al. (2006). "Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase". FASEB J. 20 (10): 1671–9. doi:10.1096/fj.06-5762com. PMID 16873890. S2CID 8233317.