UBL3

Protein-coding gene in the species Homo sapiens
UBL3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2GOW

Identifiers
AliasesUBL3, HCG-1, PNSC1, ubiquitin like 3
External IDsOMIM: 604711; MGI: 1344373; HomoloGene: 5153; GeneCards: UBL3; OMA:UBL3 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for UBL3
Genomic location for UBL3
Band13q12.3Start29,764,371 bp[1]
End29,850,617 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for UBL3
Genomic location for UBL3
Band5|5 G3Start148,504,635 bp[2]
End148,552,789 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • inferior olivary nucleus

  • amniotic fluid

  • dorsal motor nucleus of vagus nerve

  • pars reticulata

  • subthalamic nucleus

  • Pars compacta

  • external globus pallidus

  • superior vestibular nucleus

  • postcentral gyrus

  • Region I of hippocampus proper
Top expressed in
  • extensor digitorum longus muscle

  • Rostral migratory stream

  • plantaris muscle

  • corneal stroma

  • extraocular muscle

  • olfactory epithelium

  • cardiac muscle tissue of left ventricle

  • CA3 field

  • dorsal striatum

  • spermatid
More reference expression data
BioGPS


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5412

24109

Ensembl

ENSG00000122042

ENSMUSG00000001687

UniProt

O95164

Q9Z2M6

RefSeq (mRNA)

NM_007106

NM_011908

RefSeq (protein)

NP_009037

NP_036038
NP_001346128
NP_001346129
NP_001346130
NP_001346131

Location (UCSC)Chr 13: 29.76 – 29.85 MbChr 5: 148.5 – 148.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-like protein 3 is a protein that in humans is encoded by the UBL3 gene.[5][6]

In melanocytic cells UBL3 gene expression may be regulated by MITF.[7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122042 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001687 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chadwick BP, Kidd T, Sgouros J, Ish-Horowicz D, Frischauf AM (Aug 1999). "Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene". Gene. 233 (1–2): 189–95. doi:10.1016/S0378-1119(99)00138-9. PMID 10375635.
  6. ^ "Entrez Gene: UBL3 ubiquitin-like 3".
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Downes BP, Saracco SA, Lee SS, et al. (2006). "MUBs, a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation". J. Biol. Chem. 281 (37): 27145–57. doi:10.1074/jbc.M602283200. PMID 16831869.
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  • 1wgh: Solution Structure of Mouse Ubiquitin-like 3 Protein
    1wgh: Solution Structure of Mouse Ubiquitin-like 3 Protein
  • 2gow: Solution structure of BC059385 from Homo sapiens
    2gow: Solution structure of BC059385 from Homo sapiens


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