SH2D4A

Protein-coding gene in the species Homo sapiens
SH2D4A
Identifiers
AliasesSH2D4A, PPP1R38, SH2A, SH2 domain containing 4A
External IDsOMIM: 614968; MGI: 1919531; HomoloGene: 11117; GeneCards: SH2D4A; OMA:SH2D4A - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for SH2D4A
Genomic location for SH2D4A
Band8p21.3Start19,313,693 bp[1]
End19,396,218 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for SH2D4A
Genomic location for SH2D4A
Band8|8 B3.3Start68,729,219 bp[2]
End68,800,351 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • Achilles tendon

  • amniotic fluid

  • buccal mucosa cell

  • palpebral conjunctiva

  • left ovary

  • testicle

  • pylorus

  • parotid gland

  • right lobe of liver
Top expressed in
  • epithelium of stomach

  • parotid gland

  • left colon

  • urothelium

  • left lung lobe

  • transitional epithelium of urinary bladder

  • skin of external ear

  • esophagus

  • medullary collecting duct

  • right lung lobe
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • phosphatase binding
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • negative regulation of phosphatase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

63898

72281

Ensembl

ENSG00000104611

ENSMUSG00000053886

UniProt

Q9H788

Q9D7V1

RefSeq (mRNA)

NM_001174159
NM_001174160
NM_022071
NM_001363110
NM_001363111

NM_028182

RefSeq (protein)

NP_001167630
NP_001167631
NP_071354
NP_001350039
NP_001350040

NP_082458

Location (UCSC)Chr 8: 19.31 – 19.4 MbChr 8: 68.73 – 68.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SH2 domain-containing protein 4A is a protein that in humans is encoded by the SH2D4A gene.[5]

Interactions

SH2D4A has been shown to interact with MAGEA11.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104611 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053886 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SH2D4A SH2 domain containing 4A".
  6. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Dai S, Zhao Y, Ding Q (2003). "[A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 19 (6): 458–462. PMID 12476414.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • v
  • t
  • e