RBBP6

Protein-coding gene in the species Homo sapiens

RBBP6

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2C7H, 2YSA, 2YUR, 3ZTG

Identifiers

Aliases

RBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA, retinoblastoma binding protein 6, RB binding protein 6, ubiquitin ligase

External IDs

OMIM: 600938; MGI: 894835; HomoloGene: 136812; GeneCards: RBBP6; OMA:RBBP6 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p12.1	Start	24,537,693 bp^[1]
Band	16p12.1	End	24,572,863 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 F2	Start	122,564,909 bp^[2]
Band	7\|7 F2	End	122,601,780 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

buccal mucosa cell

sperm

gastric mucosa

left ovary

mucosa of paranasal sinus

right ovary

right uterine tube

left testis

right testis

skin of abdomen

Top expressed in

tail of embryo

genital tubercle

medullary collecting duct

neural layer of retina

ventricular zone

Ileal epithelium

thymus

spermatid

plantaris muscle

renal corpuscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding zinc ion binding nucleic acid binding metal ion binding ubiquitin-protein transferase activity ubiquitin protein ligase activity transferase activity RNA binding protein kinase binding
Cellular component	nucleolus microtubule organizing center nucleus chromosome cytoplasm cytoskeleton cytosol centrosome nuclear speck protein-containing complex
Biological process	in utero embryonic development embryonic organ development regulation of DNA replication DNA replication cellular response to DNA damage stimulus protein ubiquitination multicellular organism growth somite development mRNA processing protein polyubiquitination ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5930


19647

Ensembl


ENSG00000122257


ENSMUSG00000030779

UniProt


Q7Z6E9


P97868

RefSeq (mRNA)


NM_006910 NM_018703 NM_032626


NM_011247 NM_175023

RefSeq (protein)


NP_008841 NP_061173 NP_116015


NP_035377 NP_778188 NP_001390011 NP_001390012

Location (UCSC)

Chr 16: 24.54 – 24.57 Mb

Chr 7: 122.56 – 122.6 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Retinoblastoma-binding protein 6 is a protein that in humans is encoded by the RBBP6 gene.^[5]^[6]^[7]

Function

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.^[7]

Interactions

RBBP6 has been shown to interact with Y box binding protein 1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122257 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030779 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sakai Y, Saijo M, Coelho K, Kishino T, Niikawa N, Taya Y (Nov 1995). "cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product". Genomics. 30 (1): 98–101. doi:10.1006/geno.1995.0017. PMID 8595913.
^ Pugh DJ, Ab E, Faro A, Lutya PT, Hoffmann E, Rees DJ (Feb 2006). "DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways". BMC Structural Biology. 6: 1. doi:10.1186/1472-6807-6-1. PMC 1360078. PMID 16396680.
^ ^a ^b "Entrez Gene: RBBP6 retinoblastoma binding protein 6".
^ Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (Dec 2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". Journal of Molecular Biology. 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID 18851979.

Simons A, Melamed-Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, Rotter V (Jan 1997). "PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb". Oncogene. 14 (2): 145–55. doi:10.1038/sj.onc.1200825. PMID 9010216.
Gao S, Witte MM, Scott RE (May 2002). "P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity". Journal of Cellular Physiology. 191 (2): 145–54. doi:10.1002/jcp.10084. PMID 12064457. S2CID 25240477.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Yoshitake Y, Nakatsura T, Monji M, Senju S, Matsuyoshi H, Tsukamoto H, Hosaka S, Komori H, Fukuma D, Ikuta Y, Katagiri T, Furukawa Y, Ito H, Shinohara M, Nakamura Y, Nishimura Y (Oct 2004). "Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis". Clinical Cancer Research. 10 (19): 6437–48. doi:10.1158/1078-0432.CCR-04-0841. PMID 15475430.
Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW (Jul 2005). "P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA". Journal of Cellular Physiology. 204 (1): 99–105. doi:10.1002/jcp.20263. PMID 15617101. S2CID 24888360.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.