PIEZO2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
6KG7

Identifiers

Aliases

PIEZO2, C18orf30, C18orf58, DA3, DA5, FAM38B, FAM38B2, HsT748, HsT771, MWKS, piezo type mechanosensitive ion channel component 2, DAIPT

External IDs

OMIM: 613629; MGI: 1918781; HomoloGene: 49695; GeneCards: PIEZO2; OMA:PIEZO2 - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18p11.22-p11.21	Start	10,666,483 bp^[1]
Band	18p11.22-p11.21	End	11,149,569 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 E1	Start	63,143,284 bp^[2]
Band	18\|18 E1	End	63,520,254 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

corpus callosum

spinal ganglia

visceral pleura

inferior ganglion of vagus nerve

trigeminal ganglion

parietal pleura

optic nerve

Achilles tendon

inferior olivary nucleus

Top expressed in

prostate

cumulus cell

trigeminal ganglion

hand

aortic valve

ascending aorta

pituitary gland

left lung lobe

pineal gland

cornea

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	cation channel activity mechanosensitive ion channel activity
Cellular component	membrane integral component of membrane plasma membrane
Biological process	ion transmembrane transport response to mechanical stimulus ion transport response to stimulus cation transport detection of mechanical stimulus involved in sensory perception regulation of membrane potential detection of mechanical stimulus cellular response to mechanical stimulus cation transmembrane transport transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


63895


667742

Ensembl


ENSG00000154864


ENSMUSG00000041482

UniProt


Q9H5I5


Q8CD54

RefSeq (mRNA)


NM_022068 NM_173817 NM_001378183


NM_001039485 NM_172629

RefSeq (protein)


NP_071351 NP_001365112


NP_001034574

Location (UCSC)

Chr 18: 10.67 – 11.15 Mb

Chr 18: 63.14 – 63.52 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Piezo-type mechanosensitive ion channel component 2 is a protein that in humans is encoded by the PIEZO2 gene.^[5] It has a homotrimeric structure, with three blades curving into a nano-dome, with a diameter of 28 nanometers.^[6]

Function

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons.^[7] Its structure is resolved via a mouse version in 2019, showing the predicted homotrimeric propeller.^[8]

PIEZO2 is typically found in cell types that respond to physical touch, such as Merkel cells,^[9] and is thought to regulate light touch response.^[10]

Pathology

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis.^[11]
Mice without PIEZO2 in their proprioceptive neurons show uncoordinated body movements, indicating that PIEZO2 plays a role in mammalian proprioception.^[12]
PIEZO2 mutations link Gordon syndrome (distal arthrogryposis type 3), Marden-Walker syndrome and Arthrogryposis (Distal Arthrogryposis Type 5).^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154864 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041482 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Piezo-type mechanosensitive ion channel component 2". Retrieved 2013-08-06.
^ Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, et al. (September 2019). "Structure and mechanogating of the mammalian tactile channel PIEZO2". Nature. 573 (7773): 225–229. Bibcode:2019Natur.573..225W. doi:10.1038/s41586-019-1505-8. PMID 31435011. S2CID 201116189.
^ Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, et al. (October 2010). "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels". Science. 330 (6000): 55–60. Bibcode:2010Sci...330...55C. doi:10.1126/science.1193270. PMC 3062430. PMID 20813920.
^ Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, et al. (September 2019). "Structure and mechanogating of the mammalian tactile channel PIEZO2". Nature. 573 (7773): 225–229. Bibcode:2019Natur.573..225W. doi:10.1038/s41586-019-1505-8. PMID 31435011. S2CID 201116189.
^ Wu J, Lewis AH, Grandl J (January 2017). "Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels". Trends in Biochemical Sciences. 42 (1): 57–71. doi:10.1016/j.tibs.2016.09.004. PMC 5407468. PMID 27743844.
^ Faucherre A, Nargeot J, Mangoni ME, Jopling C (October 2013). "piezo2b regulates vertebrate light touch response". The Journal of Neuroscience. 33 (43): 17089–94. doi:10.1523/jneurosci.0522-13.2013. PMC 6618434. PMID 24155313.
^ Coste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, et al. (March 2013). "Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis". Proceedings of the National Academy of Sciences of the United States of America. 110 (12): 4667–72. Bibcode:2013PNAS..110.4667C. doi:10.1073/pnas.1221400110. PMC 3607045. PMID 23487782.
^ Woo SH, Lukacs V, de Nooij JC, Zaytseva D, Criddle CR, Francisco A, et al. (December 2015). "Piezo2 is the principal mechanotransduction channel for proprioception". Nature Neuroscience. 18 (12): 1756–62. doi:10.1038/nn.4162. PMC 4661126. PMID 26551544.
^ McMillin MJ, Beck AE, Chong JX, Shively KM, Buckingham KJ, Gildersleeve HI, et al. (May 2014). "Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5". American Journal of Human Genetics. 94 (5): 734–44. doi:10.1016/j.ajhg.2014.03.015. PMC 4067551. PMID 24726473.