Nephronectin

Protein-coding gene in the species Homo sapiens
NPNT
Identifiers
AliasesNPNT, EGFL6L, POEM, nephronectin
External IDsOMIM: 610306; MGI: 2148811; HomoloGene: 14138; GeneCards: NPNT; OMA:NPNT - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NPNT
Genomic location for NPNT
Band4q24Start105,894,775 bp[1]
End106,004,027 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for NPNT
Genomic location for NPNT
Band3|3 G3Start132,587,506 bp[2]
End132,656,052 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • right lung

  • jejunal mucosa

  • right coronary artery

  • Descending thoracic aorta

  • ascending aorta

  • lower lobe of lung

  • upper lobe of lung

  • upper lobe of left lung
Top expressed in
  • ascending aorta

  • epithelium of lens

  • aortic valve

  • left lung lobe

  • tunica media of zone of aorta

  • right lung lobe

  • calvaria

  • medullary collecting duct

  • molar

  • efferent ductule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium ion binding
  • integrin binding
  • extracellular matrix structural constituent
Cellular component
  • membrane
  • smooth muscle contractile fiber
  • extracellular matrix
  • integrin alpha8-beta1 complex
  • extracellular region
  • basement membrane
  • extracellular exosome
  • extracellular space
  • collagen-containing extracellular matrix
Biological process
  • positive regulation of transforming growth factor beta receptor signaling pathway
  • cell differentiation
  • ureteric bud development
  • establishment of protein localization
  • cellular response to tumor necrosis factor
  • extracellular matrix organization
  • cell-cell adhesion mediated by integrin
  • multicellular organism development
  • branching involved in ureteric bud morphogenesis
  • positive regulation of osteoblast differentiation
  • cell adhesion
  • pilomotor reflex
  • positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
  • positive regulation of alkaline phosphatase activity
  • positive regulation of ERK1 and ERK2 cascade
  • cell-matrix adhesion
  • positive regulation of smooth muscle contraction
  • positive regulation of cell-substrate adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

255743

114249

Ensembl

ENSG00000168743

ENSMUSG00000040998

UniProt

Q6UXI9

Q91V88

RefSeq (mRNA)
NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693

NM_198278

NM_001029836
NM_001287101
NM_001287102
NM_001287103
NM_033525

RefSeq (protein)

NP_001028219
NP_001171619
NP_001171620
NP_001171621
NP_001171622

NP_001025007
NP_001274030
NP_001274031
NP_001274032
NP_277060

Location (UCSC)Chr 4: 105.89 – 106 MbChr 3: 132.59 – 132.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nephronectin is a protein that in humans is encoded by the NPNT gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168743 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040998 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Nephronectin". Retrieved 2017-10-07.

Further reading

  • Kahai S, Lee SC, Lee DY, Yang J, Li M, Wang CH, Jiang Z, Zhang Y, Peng C, Yang BB (2009). "MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7". PLOS ONE. 4 (10): e7535. Bibcode:2009PLoSO...4.7535K. doi:10.1371/journal.pone.0007535. PMC 2760121. PMID 19844573.
  • Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YM, Chen TH, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter JI, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BH, O'Connor GT, London SJ (2010). "Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function". Nat. Genet. 42 (1): 45–52. doi:10.1038/ng.500. PMC 2832852. PMID 20010835.
  • Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
  • Nakatani S, Wei M, Ishimura E, Kakehashi A, Mori K, Nishizawa Y, Inaba M, Wanibuchi H (2012). "Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis". Nephrol. Dial. Transplant. 27 (5): 1889–97. doi:10.1093/ndt/gfr682. PMID 22172726.


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