NKIRAS2

Protein-coding gene in the species Homo sapiens
NKIRAS2
Identifiers
AliasesNKIRAS2, KBRAS2, kappaB-Ras2, NFKB inhibitor interacting Ras like 2
External IDsOMIM: 604497; MGI: 1919216; HomoloGene: 9738; GeneCards: NKIRAS2; OMA:NKIRAS2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NKIRAS2
Genomic location for NKIRAS2
Band17q21.2Start42,011,382 bp[1]
End42,025,644 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for NKIRAS2
Genomic location for NKIRAS2
Band11|11 DStart100,510,070 bp[2]
End100,518,433 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • ganglionic eminence

  • stromal cell of endometrium

  • gastrocnemius muscle

  • left ventricle

  • apex of heart

  • muscle of thigh

  • granulocyte

  • right auricle

  • popliteal artery
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • granulocyte

  • lip

  • medial ganglionic eminence

  • right ventricle

  • neural tube

  • cornea

  • esophagus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • GTPase activity
Cellular component
  • cytoplasm
  • membrane
  • cellular component
Biological process
  • I-kappaB kinase/NF-kappaB signaling
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

28511

71966

Ensembl

ENSG00000168256

ENSMUSG00000017837

UniProt

Q9NYR9

Q9CR56

RefSeq (mRNA)

NM_001001349
NM_001144927
NM_001144928
NM_001144929
NM_017595

NM_028024

RefSeq (protein)
NP_001001349
NP_001138399
NP_001138400
NP_001138401
NP_060065

NP_001001349.1
NP_001138399.1
NP_060065.2

NP_082300

Location (UCSC)Chr 17: 42.01 – 42.03 MbChr 11: 100.51 – 100.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NF-κB inhibitor interacting Ras-like 2 is a protein that in humans is encoded by the NKIRAS2 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168256 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017837 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NFKB inhibitor interacting Ras-like 2". Retrieved 2011-08-30.

Further reading

  • Tago K, Funakoshi-Tago M, Sakinawa M, Mizuno N, Itoh H (Oct 2010). "KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA". The Journal of Biological Chemistry. 285 (40): 30622–33. doi:10.1074/jbc.M110.117028. PMC 2945557. PMID 20639196.
  • Fenwick C, Na SY, Voll RE, Zhong H, Im SY, Lee JW, Ghosh S (Feb 2000). "A subclass of Ras proteins that regulate the degradation of IkappaB". Science. 287 (5454): 869–73. Bibcode:2000Sci...287..869F. doi:10.1126/science.287.5454.869. PMID 10657303.
  • Dieguez-Gonzalez R, Akar S, Calaza M, Perez-Pampin E, Costas J, Torres M, Vicario JL, Velloso ML, Navarro F, Narvaez J, Joven B, Herrero-Beaumont G, Gonzalez-Alvaro I, Fernandez-Gutierrez B, de la Serna AR, Carreño L, Lopez-Longo J, Caliz R, Collado-Escobar MD, Blanco FJ, Fernandez-Lopez C, Balsa A, Pascual-Salcedo D, Gomez-Reino JJ, Gonzalez A (Apr 2009). "Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis". Annals of the Rheumatic Diseases. 68 (4): 579–83. doi:10.1136/ard.2007.087304. PMID 18434448. S2CID 24874869.


  • v
  • t
  • e