MK-4409

Chemical compound
  • None
Legal statusLegal status
  • US: Investigational New Drug
Identifiers
  • 2-[5-[5-(5-Chloropyridin-2-yl)sulfanyl-2-(4-fluorophenyl)-1,3-oxazol-4-yl]pyridin-2-yl]propan-2-ol
CAS Number
  • 1207745-58-1 checkY
PubChem CID
  • 53341130
ChemSpider
  • 25069631
UNII
  • 77GX6MU9ZL
ChEMBL
  • ChEMBL1812717
CompTox Dashboard (EPA)
  • DTXSID101045923 Edit this at Wikidata
Chemical and physical dataFormulaC22H17FN3O2SMolar mass406.46 g·mol−13D model (JSmol)
  • Interactive image
  • c3nc(C(O)(C)C)ccc3-c1nc(-c4ccc(F)cc4)oc1Sc(nc2)ccc2Cl
InChI
  • InChI=1S/C22H17ClFN3O2S/c1-22(2,28)17-9-5-14(11-25-17)19-21(30-18-10-6-15(23)12-26-18)29-20(27-19)13-3-7-16(24)8-4-13/h3-12,28H,1-2H3
  • Key:DBZMCSVIITXLCC-UHFFFAOYSA-N

MK-4409 is an experimental drug which acts as a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 11 nM, and both analgesic and antiinflammatory effects in animal studies. It was studied for the treatment of neuropathic pain and progressed to early stage human clinical trials by 2009.[1][2]

See also

References

  1. ^ Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, et al. (June 2014). "Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain". ACS Medicinal Chemistry Letters. 5 (6): 717–21. doi:10.1021/ml5001239. PMC 4060928. PMID 24944750.
  2. ^ Merck (15 October 2009). "Merck Pipeline, Oct 2009" (PDF). Merck. Archived from the original (PDF) on 20 October 2016. Retrieved 18 January 2016.

External links

  • "MK 4409". Adis Insight. Springer Nature Switzerland AG.
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