METTL16

Protein-coding gene in the species Homo sapiens
METTL16
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2H00

Identifiers
AliasesMETTL16, METT10D, methyltransferase like 16, methyltransferase 16, N6-methyladenosine
External IDsMGI: 1914743; HomoloGene: 34653; GeneCards: METTL16; OMA:METTL16 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for METTL16
Genomic location for METTL16
Band17p13.3Start2,405,562 bp[1]
End2,511,891 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for METTL16
Genomic location for METTL16
Band11|11 B5Start74,661,656 bp[2]
End74,719,351 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • gingival epithelium

  • buccal mucosa cell

  • sperm

  • saphenous vein

  • nipple

  • urethra

  • gonad

  • germinal epithelium

  • ventricular zone
Top expressed in
  • hand

  • superior cervical ganglion

  • otolith organ

  • epiblast

  • utricle

  • supraoptic nucleus

  • tail of embryo

  • retinal pigment epithelium

  • yolk sac

  • mandibular prominence
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • methyltransferase activity
  • transferase activity
  • 23S rRNA (adenine(1618)-N(6))-methyltransferase activity
  • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
  • U6 snRNA 3'-end binding
  • RNA stem-loop binding
  • U6 snRNA (adenine-(43)-N(6))-methyltransferase activity
  • RNA binding
  • mRNA (N6-adenosine)-methyltransferase activity
Cellular component
  • nucleus
Biological process
  • rRNA base methylation
  • methylation
  • posttranscriptional regulation of gene expression
  • mRNA methylation
  • snRNA (adenine-N6)-methylation
  • mRNA processing
  • RNA splicing
  • regulation of mRNA splicing, via spliceosome
  • RNA methylation
  • mRNA catabolic process
  • S-adenosylmethionine biosynthetic process
  • mRNA destabilization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79066

67493

Ensembl

ENSG00000127804

ENSMUSG00000010554

UniProt

Q86W50

Q9CQG2

RefSeq (mRNA)

NM_024086

NM_026197

RefSeq (protein)

NP_076991

NP_080473

Location (UCSC)Chr 17: 2.41 – 2.51 MbChr 11: 74.66 – 74.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Methyltransferase like 16 is a protein that in humans is encoded by the METTL16 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127804 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010554 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Methyltransferase like 16". Retrieved 2018-01-25.

Further reading

  • Docherty SJ, Kovas Y, Petrill SA, Plomin R (2010). "Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities". BMC Genet. 11: 61. doi:10.1186/1471-2156-11-61. PMC 2909150. PMID 20602751.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human RNA N6-adenosine-methyltransferase METTL16
  • v
  • t
  • e