GGA1

Protein-coding gene in the species Homo sapiens
GGA1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1J2J, 1JWF, 1JWG, 1NA8, 1NAF, 1NWM, 1O3X, 1OM9, 1OXZ, 1PY1, 1UJJ, 1UJK, 1X79, 2DWX, 2DWY, 3G2S, 3G2T, 3G2U, 3G2V, 3G2W

Identifiers
AliasesGGA1, golgi associated, gamma adaptin ear containing, ARF binding protein 1
External IDsOMIM: 606004; MGI: 2146207; HomoloGene: 39250; GeneCards: GGA1; OMA:GGA1 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for GGA1
Genomic location for GGA1
Band22q13.1Start37,608,725 bp[1]
End37,633,564 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for GGA1
Genomic location for GGA1
Band15|15 E1Start78,761,390 bp[2]
End78,778,785 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • left testis

  • right testis

  • endothelial cell

  • right uterine tube

  • mucosa of ileum

  • right hemisphere of cerebellum

  • pituitary gland

  • gingival epithelium

  • anterior pituitary
Top expressed in
  • granulocyte

  • muscle of thigh

  • lip

  • pyloric antrum

  • yolk sac

  • superior frontal gyrus

  • ventricular zone

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • esophagus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein heterodimerization activity
  • molecular function
Cellular component
  • endosome
  • Golgi apparatus
  • endosome membrane
  • intracellular anatomical structure
  • membrane
  • intracellular membrane-bounded organelle
  • clathrin adaptor complex
  • nucleoplasm
  • early endosome membrane
  • early endosome
  • cytosol
  • protein-containing complex
Biological process
  • protein transport
  • intracellular protein transport
  • toxin transport
  • positive regulation of protein catabolic process
  • vesicle-mediated transport
  • transport
  • Golgi to plasma membrane transport
  • protein localization
  • protein localization to cell surface
  • retrograde transport, endosome to Golgi
  • Golgi to plasma membrane protein transport
  • protein localization to ciliary membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26088

106039

Ensembl

ENSG00000100083

ENSMUSG00000033128

UniProt

Q9UJY5

Q8R0H9

RefSeq (mRNA)
NM_001001560
NM_001001561
NM_001172687
NM_001172688
NM_013365

NM_001363771

NM_145929

RefSeq (protein)

NP_001001560
NP_001166158
NP_001166159
NP_037497
NP_001350700

NP_666041

Location (UCSC)Chr 22: 37.61 – 37.63 MbChr 15: 78.76 – 78.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.[5][6][7]

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[8]

Interactions

GGA1 has been shown to interact with Sortilin 1,[9] BACE2,[10] RABEP1[11] and ARF3.[12][13]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100083 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033128 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (May 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J Cell Biol. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
  6. ^ Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (May 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J Cell Biol. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089.
  7. ^ Xie L, Boyle D, Sanford D, Scherer PE, Pessin JE, Mora S (March 2006). "Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles". J Biol Chem. 281 (11): 7253–9. doi:10.1074/jbc.M511313200. hdl:2445/176753. PMID 16407204.
  8. ^ "Entrez Gene: GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1".
  9. ^ Jacobsen, Linda; Madsen Peder; Nielsen Morten S; Geraerts Wijnand P M; Gliemann Jørgen; Smit August B; Petersen Claus M (January 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. ISSN 0014-5793. PMID 11821067. S2CID 21977507.
  10. ^ He, Xiangyuan; Chang Wan-Pin; Koelsch Gerald; Tang Jordan (July 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. ISSN 0014-5793. PMID 12135764.
  11. ^ Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMC 140067. PMID 12505986.
  12. ^ Boman, Annette L; Salo Paul D; Hauglund Melissa J; Strand Nicole L; Rensink Shelly J; Zhdankina Olga (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. ISSN 1059-1524. PMC 124144. PMID 12221117.
  13. ^ Boman, A L; Zhang C j; Zhu X; Kahn R A (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. ISSN 1059-1524. PMC 14844. PMID 10749927.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Boman AL, Zhang C, Zhu X, Kahn RA (2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844. PMID 10749927.
  • Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
  • Zhdankina O, Strand NL, Redmond JM, Boman AL (2001). "Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi". Yeast. 18 (1): 1–18. doi:10.1002/1097-0061(200101)18:1<1::AID-YEA644>3.0.CO;2-5. PMID 11124697. S2CID 10348751.
  • Puertollano R, Randazzo PA, Presley JF, et al. (2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005.
  • Puertollano R, Aguilar RC, Gorshkova I, et al. (2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science. 292 (5522): 1712–6. Bibcode:2001Sci...292.1712P. doi:10.1126/science.1060750. PMID 11387475. S2CID 30836125.
  • Takatsu H, Katoh Y, Shiba Y, Nakayama K (2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains". J. Biol. Chem. 276 (30): 28541–5. doi:10.1074/jbc.C100218200. PMID 11390366.
  • Jacobsen L, Madsen P, Nielsen MS, et al. (2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. PMID 11821067. S2CID 21977507.
  • Shiba T, Takatsu H, Nogi T, et al. (2002). "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1". Nature. 415 (6874): 937–41. Bibcode:2002Natur.415..937S. doi:10.1038/415937a. PMID 11859376. S2CID 4395774.
  • Takatsu H, Yoshino K, Toda K, Nakayama K (2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". Biochem. J. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC 1222692. PMID 11950392.
  • Doray B, Bruns K, Ghosh P, Kornfeld SA (2002). "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8072–7. Bibcode:2002PNAS...99.8072D. doi:10.1073/pnas.082235699. PMC 123022. PMID 12060753.
  • He X, Chang WP, Koelsch G, Tang J (2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. PMID 12135764.
  • Boman AL, Salo PD, Hauglund MJ, et al. (2003). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC 124144. PMID 12221117.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mattera R, Arighi CN, Lodge R, et al. (2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
  • Mills IG, Praefcke GJ, Vallis Y, et al. (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking". J. Cell Biol. 160 (2): 213–22. doi:10.1083/jcb.200208023. PMC 2172650. PMID 12538641.
  • v
  • t
  • e
  • 1j2j: Crystal structure of GGA1 GAT N-terminal region in complex with ARF1 GTP form
    1j2j: Crystal structure of GGA1 GAT N-terminal region in complex with ARF1 GTP form
  • 1jwf: Crystal Structure of human GGA1 VHS domain.
    1jwf: Crystal Structure of human GGA1 VHS domain.
  • 1jwg: VHS Domain of human GGA1 complexed with cation-independent M6PR C-terminal Peptide
    1jwg: VHS Domain of human GGA1 complexed with cation-independent M6PR C-terminal Peptide
  • 1na8: Crystal structure of ADP-ribosylation factor binding protein GGA1
    1na8: Crystal structure of ADP-ribosylation factor binding protein GGA1
  • 1naf: crystal structure of the human GGA1 GAT domain
    1naf: crystal structure of the human GGA1 GAT domain
  • 1nwm: GAT domain of human GGA1
    1nwm: GAT domain of human GGA1
  • 1o3x: Crystal structure of human GGA1 GAT domain
    1o3x: Crystal structure of human GGA1 GAT domain
  • 1om9: Structure of the GGA1-appendage in complex with the p56 binding peptide
    1om9: Structure of the GGA1-appendage in complex with the p56 binding peptide
  • 1oxz: Crystal Structure of the Human GGA1 GAT domain
    1oxz: Crystal Structure of the Human GGA1 GAT domain
  • 1py1: Complex of GGA1-VHS domain and beta-secretase C-terminal phosphopeptide
    1py1: Complex of GGA1-VHS domain and beta-secretase C-terminal phosphopeptide
  • 1ujj: VHS domain of human GGA1 complexed with C-terminal peptide from BACE
    1ujj: VHS domain of human GGA1 complexed with C-terminal peptide from BACE
  • 1ujk: VHS domain of human GGA1 complexed with C-terminal phosphopeptide from BACE
    1ujk: VHS domain of human GGA1 complexed with C-terminal phosphopeptide from BACE
  • 1x79: Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5
    1x79: Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5
  • 2dwx: Co-crystal Structure Analysis of GGA1-GAE with the WNSF motif
    2dwx: Co-crystal Structure Analysis of GGA1-GAE with the WNSF motif
  • 2dwy: Crystal Structure Analysis of GGA1-GAE
    2dwy: Crystal Structure Analysis of GGA1-GAE