Ferric derisomaltose

Medication

US DailyMed: Ferric_derisomaltose

Routes of
administrationIntravenous (IV)ATC code

None

Legal statusLegal status

AU: S4 (Prescription only)^[1]^[2]
CA: ℞-only^[3]
US: ℞-only^[4]

Identifiers

IUPAC name

iron(3+);(2S,3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexane-1,2,3,4,5-pentol

CAS Number

1345510-43-1

PubChem CID

86278348

DrugBank

DB15617

UNII

AHU547PI9H

KEGG

D11808

Chemical and physical dataFormulaC₁₈H₃₄FeO₁₆⁺³Molar mass562.299 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(CO)O)O)O)O)O)O)O)O)O)O)O.[Fe+3]

InChI

InChI=1S/C18H34O16.Fe/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18;/h5-30H,1-4H2;/q;+3/t5-,6+,7+,8+,9+,10+,11+,12+,13-,14-,15+,16+,17-,18-;/m0./s1
Key:JTQTXQSGPZRXJF-DOJSGGEQSA-N

Ferric derisomaltose (FDI), sold under the brand name Monoferric among others, is a medication for the treatment of iron deficiency anemia (IDA) in adults who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have non-hemodialysis dependent chronic kidney disease (NDD-CKD).^[4] It was approved for use in the United States in January 2020.^[4]^[5]^[6] It is given intravenously.^[4]

References

^ "Monofer iron (as ferric derisomaltose) 1000 mg/10 mL solution for injection vial (290834)". Therapeutic Goods Administration (TGA). 26 May 2022. Retrieved 9 April 2023.
^ "Prescription medicines and biologicals: TGA annual summary 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 31 March 2024.
^ "Search Page - Drug and Health Product Register". 23 October 2014.
^ ^a ^b ^c ^d "Monoferric- ferric derisomaltose solution". DailyMed. 24 January 2020. Retrieved 16 February 2020.
^ "Monoferric approval letter" (PDF). U.S. Food and Drug Administration (FDA). 16 January 2020. Retrieved 16 February 2020. This article incorporates text from this source, which is in the public domain.
^ "Drug Approval Package: Monoferric Injection". U.S. Food and Drug Administration (FDA). 7 May 2020. Retrieved 13 August 2020.