Cytokine dependent hematopoietic cell linker

Protein-coding gene in the species Homo sapiens
CLNK
Identifiers
AliasesCLNK, MIST, cytokine dependent hematopoietic cell linker
External IDsOMIM: 611434; MGI: 1351468; HomoloGene: 8450; GeneCards: CLNK; OMA:CLNK - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CLNK
Genomic location for CLNK
Band4p16.1Start10,486,395 bp[1]
End10,684,768 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for CLNK
Genomic location for CLNK
Band5|5 B3Start38,863,805 bp[2]
End39,034,155 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • human kidney

  • lymph node

  • renal medulla

  • thymus

  • pharynx

  • corpus epididymis

  • epithelium of nasopharynx

  • cecum

  • gonad
Top expressed in
  • embryo

  • embryo

  • spermatid

  • blastocyst

  • right kidney

  • gastrula

  • duodenum

  • jejunum

  • spermatocyte

  • esophagus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • intracellular anatomical structure
Biological process
  • intracellular signal transduction
  • immune response
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • positive regulation of signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116449

27278

Ensembl

ENSG00000109684

ENSMUSG00000039315

UniProt

Q7Z7G1

Q9QZE2

RefSeq (mRNA)

NM_052964

NM_013748

RefSeq (protein)

NP_443196

NP_038776

Location (UCSC)Chr 4: 10.49 – 10.68 MbChr 5: 38.86 – 39.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene. [5]

Function

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109684 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039315 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Cytokine dependent hematopoietic cell linker". Retrieved 2017-09-06.

Further reading

  • Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O (2009). "Screening for replication of genome-wide SNP associations in sporadic ALS". Eur. J. Hum. Genet. 17 (2): 213–8. doi:10.1038/ejhg.2008.194. PMC 2986065. PMID 18987618.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Jin TB, Ren Y, Shi X, Jiri M, He N, Feng T, Yuan D, Kang L (2015). "Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets". Rheumatol. Int. 35 (7): 1141–7. doi:10.1007/s00296-015-3215-3. PMID 25591661. S2CID 23426576.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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