Protein-coding gene in the species Homo sapiens
CLNK |
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Identifiers |
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Aliases | CLNK, MIST, cytokine dependent hematopoietic cell linker |
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External IDs | OMIM: 611434; MGI: 1351468; HomoloGene: 8450; GeneCards: CLNK; OMA:CLNK - orthologs |
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Gene location (Human) |
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![Chromosome 4 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_human_chromosome_4.svg/300px-Ideogram_human_chromosome_4.svg.png) | Chr. | Chromosome 4 (human)[1] |
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| Band | 4p16.1 | Start | 10,486,395 bp[1] |
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End | 10,684,768 bp[1] |
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Gene location (Mouse) |
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![Chromosome 5 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png) | Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 B3 | Start | 38,863,805 bp[2] |
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End | 39,034,155 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - buccal mucosa cell
- human kidney
- lymph node
- renal medulla
- thymus
- pharynx
- corpus epididymis
- epithelium of nasopharynx
- cecum
- gonad
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| Top expressed in | - embryo
- embryo
- spermatid
- blastocyst
- right kidney
- gastrula
- duodenum
- jejunum
- spermatocyte
- esophagus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - intracellular anatomical structure
| Biological process | - intracellular signal transduction
- immune response
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of signal transduction
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 4: 10.49 – 10.68 Mb | Chr 5: 38.86 – 39.03 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene. [5]
Function
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000109684 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039315 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Cytokine dependent hematopoietic cell linker". Retrieved 2017-09-06.
Further reading
- Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O (2009). "Screening for replication of genome-wide SNP associations in sporadic ALS". Eur. J. Hum. Genet. 17 (2): 213–8. doi:10.1038/ejhg.2008.194. PMC 2986065. PMID 18987618.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Jin TB, Ren Y, Shi X, Jiri M, He N, Feng T, Yuan D, Kang L (2015). "Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets". Rheumatol. Int. 35 (7): 1141–7. doi:10.1007/s00296-015-3215-3. PMID 25591661. S2CID 23426576.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.