CHAMP1

Protein-coding gene in the species Homo sapiens
CHAMP1
Identifiers
AliasesCHAMP1, C13orf8, CAMP, CHAMP, ZNF828, MRD40, chromosome alignment maintaining phosphoprotein 1
External IDsOMIM: 616327; MGI: 1196398; HomoloGene: 18780; GeneCards: CHAMP1; OMA:CHAMP1 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for CHAMP1
Genomic location for CHAMP1
Band13q34Start114,314,482 bp[1]
End114,337,626 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CHAMP1
Genomic location for CHAMP1
Band8 A1.1|8 6.4 cMStart13,919,641 bp[2]
End13,931,639 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • secondary oocyte

  • ganglionic eminence

  • epithelium of colon

  • tibialis anterior muscle

  • cardiac muscle tissue of right atrium

  • thymus

  • skin of thigh

  • myocardium of left ventricle

  • stromal cell of endometrium
Top expressed in
  • hand

  • zygote

  • oocyte

  • secondary oocyte

  • primary oocyte

  • otolith organ

  • utricle

  • maxillary prominence

  • epiblast

  • primitive streak
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • nucleic acid binding
Cellular component
  • cytoplasm
  • chromosome
  • spindle
  • chromosome, centromeric region
  • cytoskeleton
  • condensed chromosome
  • nucleus
  • kinetochore
  • nucleoplasm
  • Flemming body
Biological process
  • sister chromatid biorientation
  • protein localization to microtubule
  • attachment of mitotic spindle microtubules to kinetochore
  • protein localization to kinetochore
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

283489

101994

Ensembl

ENSG00000198824

ENSMUSG00000047710

UniProt

Q96JM3

Q8K327

RefSeq (mRNA)

NM_032436
NM_001164144
NM_001164145

NM_181854
NM_001363455

RefSeq (protein)

NP_001157616
NP_001157617
NP_115812

NP_862902
NP_001350384

Location (UCSC)Chr 13: 114.31 – 114.34 MbChr 8: 13.92 – 13.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromosome alignment-maintaining phosphoprotein 1 (CHAMP1) also known as zinc finger protein 828 (ZNF828) is a protein that in humans is encoded by the CHAMP1 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198824 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047710 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: C13orf8 chromosome 13 open reading frame 8".

External links

  • CHAMP1 UK - Charity for those affected by CHAMP1 disorders.
  • CHAMP1 Research Foundation - Non-Profit raising funds for research into CHAMP1 and CHAMP1 disorders.
  • Human CAMP genome location and CAMP gene details page in the UCSC Genome Browser.
  • Human CHAMP1 genome location and CHAMP1 gene details page in the UCSC Genome Browser.

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
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