CDH17

Protein-coding gene in the species Homo sapiens
CDH17
Identifiers
AliasesCDH17, CDH16, HPT-1, HPT1, cadherin 17
External IDsOMIM: 603017; MGI: 1095414; HomoloGene: 56859; GeneCards: CDH17; OMA:CDH17 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for CDH17
Genomic location for CDH17
Band8q22.1Start94,127,162 bp[1]
End94,217,303 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for CDH17
Genomic location for CDH17
Band4|4 A1Start11,758,147 bp[2]
End11,817,895 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of colon

  • mucosa of sigmoid colon

  • mucosa of ileum

  • jejunal mucosa

  • rectum

  • mucosa of transverse colon

  • duodenum

  • pancreatic ductal cell

  • secondary oocyte

  • appendix
Top expressed in
  • ileum

  • intestinal villus

  • left colon

  • duodenum

  • epithelium of small intestine

  • crypt of lieberkuhn of small intestine

  • jejunum

  • migratory enteric neural crest cell

  • Paneth cell

  • zygote
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • transporter activity
  • metal ion binding
  • integrin binding
  • proton-dependent oligopeptide secondary active transmembrane transporter activity
  • cytoskeletal protein binding
  • protein homodimerization activity
  • cadherin binding
Cellular component
  • integral component of membrane
  • membrane
  • cell surface
  • plasma membrane
  • basolateral plasma membrane
  • nucleus
  • cell junction
  • catenin complex
Biological process
  • spleen development
  • marginal zone B cell differentiation
  • integrin-mediated signaling pathway
  • positive regulation of integrin activation by cell surface receptor linked signal transduction
  • germinal center B cell differentiation
  • B cell differentiation
  • adherens junction organization
  • oligopeptide transport
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
  • oligopeptide transmembrane transport
  • homophilic cell adhesion via plasma membrane adhesion molecules
  • cell adhesion
  • cell-cell junction assembly
  • cell-cell adhesion mediated by cadherin
  • cell-cell adhesion
  • cell morphogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1015

12557

Ensembl

ENSG00000079112

ENSMUSG00000028217

UniProt

Q12864

Q9R100

RefSeq (mRNA)

NM_001144663
NM_004063

NM_019753

RefSeq (protein)

NP_001138135
NP_004054

NP_062727

Location (UCSC)Chr 8: 94.13 – 94.22 MbChr 4: 11.76 – 11.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[5][6][7]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079112 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028217 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
  6. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
  7. ^ a b "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)".

Further reading

  • Gessner R, Tauber R (2001). "Intestinal cell adhesion molecules. Liver-intestine cadherin". Ann. N. Y. Acad. Sci. 915: 136–43. doi:10.1111/j.1749-6632.2000.tb05236.x. PMID 11193569. S2CID 27317315.
  • Gilston A (1978). "Reducing the hazard of disconnected tubes". Anaesthesia. 32 (9): 922. doi:10.1111/j.1365-2044.1977.tb10133.x. PMID 603017. S2CID 31703359.
  • Dantzig AH, Hoskins JA, Tabas LB, et al. (1994). "Association of intestinal peptide transport with a protein related to the cadherin superfamily". Science. 264 (5157): 430–3. Bibcode:1994Sci...264..430D. doi:10.1126/science.8153632. PMID 8153632.
  • Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
  • Grötzinger C, Kneifel J, Patschan D, et al. (2001). "LI-cadherin: a marker of gastric metaplasia and neoplasia". Gut. 49 (1): 73–81. doi:10.1136/gut.49.1.73. PMC 1728355. PMID 11413113.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Takamura M, Sakamoto M, Ino Y, et al. (2003). "Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas". Cancer Sci. 94 (5): 425–30. doi:10.1111/j.1349-7006.2003.tb01459.x. PMC 11160223. PMID 12824888. S2CID 25229564.
  • Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID 15023525.
  • Ko S, Chu KM, Luk JM, et al. (2004). "Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis". Biochem. Biophys. Res. Commun. 319 (2): 562–8. doi:10.1016/j.bbrc.2004.04.197. PMID 15178443.
  • Takamura M, Ichida T, Matsuda Y, et al. (2004). "Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma". Cancer Lett. 212 (2): 253–9. doi:10.1016/j.canlet.2004.03.016. PMID 15279905.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Wang XQ, Luk JM, Leung PP, et al. (2005). "Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma". Clin. Cancer Res. 11 (2 Pt 1): 483–9. doi:10.1158/1078-0432.483.11.2. PMID 15701831.
  • Wang XQ, Luk JM, Garcia-Barcelo M, et al. (2007). "Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma". Clin. Cancer Res. 12 (17): 5248–52. doi:10.1158/1078-0432.CCR-06-0558. PMID 16951245. S2CID 22423581.

External links


Stub icon

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e