CDC48_N |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/d/d4/PDB_1s3s_EBI.jpg/220px-PDB_1s3s_EBI.jpg) crystal structure of aaa atpase p97/vcp nd1 in complex with p47 c |
Identifiers |
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Symbol | CDC48_N |
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Pfam | PF02359 |
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InterPro | IPR003338 |
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SCOP2 | 1cz4 / SCOPe / SUPFAM |
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Available protein structures: |
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Pfam | structures / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | structure summary |
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CDC48_2 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/3/34/PDB_1qdn_EBI.jpg/220px-PDB_1qdn_EBI.jpg) amino terminal domain of the n-ethylmaleimide sensitive fusion protein (nsf) |
Identifiers |
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Symbol | CDC48_2 |
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Pfam | PF02933 |
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Pfam clan | CL0402 |
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InterPro | IPR004201 |
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SCOP2 | 1cz4 / SCOPe / SUPFAM |
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Available protein structures: |
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Pfam | structures / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | structure summary |
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In molecular biology, the CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase and N-ethylmaleimide sensitive fusion protein. It is a substrate recognition domain which binds polypeptides, prevents protein aggregation, and catalyses refolding of permissive substrates. It is composed of two equally sized subdomains. The amino-terminal subdomain (CDC48_N) forms a double-psi beta-barrel whose pseudo-twofold symmetry is mirrored by an internal sequence repeat of 42 residues. The carboxy-terminal subdomain (CDC48_2) forms a novel six-stranded beta-clam fold.[1] Together these subdomains form a kidney-shaped structure, in close agreement with results from electron microscopy. CDC48_N is related to numerous proteins including prokaryotic transcription factors, metabolic enzymes, the protease cofactors UFD1 and PrlF, and aspartic proteinases.
References
- ^ Coles M, Diercks T, Liermann J, Groger A, Rockel B, Baumeister W, Koretke KK, Lupas A, Peters J, Kessler H (October 1999). "The solution structure of VAT-N reveals a 'missing link' in the evolution of complex enzymes from a simple betaalphabetabeta element". Curr. Biol. 9 (20): 1158–68. doi:10.1016/S0960-9822(00)80017-2. PMID 10531028. S2CID 6561497.
This article incorporates text from the public domain
Pfam and
InterPro: IPR003338
This article incorporates text from the public domain
Pfam and
InterPro: IPR004201