ACTR3B

Gene of the species Homo sapiens
ACTR3B
Identifiers
AliasesACTR3B, ARP11, ARP3BETA, ARP3 actin-related protein 3 homolog B (yeast)
External IDsMGI: 2661120; HomoloGene: 4180; GeneCards: ACTR3B; OMA:ACTR3B - orthologs
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[1]
Chromosome 5 (mouse)
Genomic location for ACTR3B
Genomic location for ACTR3B
Band5|5 B1Start25,964,995 bp[1]
End26,055,686 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
    n/a
Top expressed in
  • hippocampus proper

  • dorsal striatum

  • olfactory tubercle

  • dentate gyrus

  • visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • primary visual cortex

  • piriform cortex

  • subdivision of hippocampus
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ATP binding
  • nucleotide binding
  • actin binding
  • molecular function
  • actin filament binding
Cellular component
  • arp2/3 protein complex
  • cell projection
  • cytoplasm
  • cytoskeleton
  • extracellular exosome
Biological process
  • actin filament organization
  • Arp2/3 complex-mediated actin nucleation
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57180

242894

Ensembl

ENSG00000133627

ENSMUSG00000056367

UniProt

Q9P1U1

Q641P0

RefSeq (mRNA)

NM_001040135
NM_020445

NM_001004365
NM_001310504

RefSeq (protein)
NP_001035225
NP_065178
NP_001337869
NP_001337870
NP_001337871

NP_001337872
NP_001337873
NP_001337874
NP_001337875

NP_001004365
NP_001297433

Location (UCSC)n/aChr 5: 25.96 – 26.06 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene.[4] Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.[4]

Function

This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility.[4]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056367 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b c "Entrez Gene: ACTR3B ARP3 actin-related protein 3 homolog B (yeast)".

External links

Further reading

  • Machesky LM, Gould KL (Feb 1999). "The Arp2/3 complex: a multifunctional actin organizer". Current Opinion in Cell Biology. 11 (1): 117–21. doi:10.1016/S0955-0674(99)80014-3. PMID 10047519.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Shindo-Okada N, Iigo M (Dec 2003). "Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells". Biochemical and Biophysical Research Communications. 312 (4): 889–96. doi:10.1016/j.bbrc.2003.10.200. PMID 14651955.
  • Shindo-Okada N, Shimizu K (Jan 2001). "Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma". Biochemical and Biophysical Research Communications. 280 (1): 61–7. doi:10.1006/bbrc.2000.4059. PMID 11162478.
  • Jay P, Bergé-Lefranc JL, Massacrier A, Roessler E, Wallis D, Muenke M, Gastaldi M, Taviaux S, Cau P, Berta P (May 2000). "ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells". European Journal of Biochemistry. 267 (10): 2921–8. doi:10.1046/j.1432-1327.2000.01306.x. PMID 10806390.
  • v
  • t
  • e
  • 1k8k: Crystal Structure of Arp2/3 Complex
    1k8k: Crystal Structure of Arp2/3 Complex
  • 1tyq: Crystal structure of Arp2/3 complex with bound ATP and calcium
    1tyq: Crystal structure of Arp2/3 complex with bound ATP and calcium
  • 1u2v: Crystal structure of Arp2/3 complex with bound ADP and calcium
    1u2v: Crystal structure of Arp2/3 complex with bound ADP and calcium
  • 2p9i: Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with gluteraldehyde
    2p9i: Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with gluteraldehyde
  • 2p9k: Crystal structure of bovine Arp2/3 complex co-crystallized with ATP and crosslinked with glutaraldehyde
    2p9k: Crystal structure of bovine Arp2/3 complex co-crystallized with ATP and crosslinked with glutaraldehyde
  • 2p9l: Crystal Structure of bovine Arp2/3 complex
    2p9l: Crystal Structure of bovine Arp2/3 complex
  • 2p9n: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
    2p9n: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
  • 2p9p: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
    2p9p: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
  • 2p9s: Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+
    2p9s: Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+
  • 2p9u: Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium
    2p9u: Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Stub icon

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e