4-Hydroxy-4-methylpentanoic acid
Chemical compound
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Other names | 4-Hydroxy-4-methylpentanoic acid |
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Formula | C6H12O3 |
Molar mass | 132.159 g·mol−1 |
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4-Hydroxy-4-methylpentanoic acid (UMB68) is a tertiary alcohol, similar in structure to the drug GHB. The molecule has been synthesized and tested on animals in order to further research the effects of GHB. UMB68 has been shown to bind selectively to the GHB receptor ligand in binding assays, yet does not bind to GABAergic receptors. As such, it can provide a useful tool in studying the pharmacology of the GHB receptor in absence of GABAergic effects.[1]
References
- ^ Wu H, Zink N, Carter LP, Mehta AK, Hernandez RJ, Ticku MK, Lamb R, France CP, Coop A (2003). "A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand". Journal of Pharmacology and Experimental Therapeutics. 305 (2): 675–679. doi:10.1124/jpet.102.046797. PMID 12606613. S2CID 86191608.
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GHB receptor modulators
(ligands)
GHBRTooltip GHB receptor |
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GABABTooltip γ-Aminobutyric acid B receptor |
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(blockers)
MCTsTooltip Monocarboxylate transporters | |
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SMCTsTooltip Sodium-coupled monocarboxylate transporters | |
VIATTTooltip Vesicular inhibitory amino acid transporter |
(inhibitors)
SSRTooltip Succinic semialdehyde reductase | |
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GHBDHTooltip 4-Hydroxybutyrate dehydrogenase |
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HOTTooltip Hydroxyacid-oxoacid transhydrogenase | |
ADHTooltip Alcohol dehydrogenase | |
ALDHTooltip Aldehyde dehydrogenase |
- See also
- Receptor/signaling modulators
- GABA receptor modulators
- Glutamate receptor modulators
- Glycine receptor modulators
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